Discuss the major problem involoved in the develpoment of anticancer Essay

Discuss the major problem involoved in the develpoment of anticancer agents today include in ur answer some discussion what step might be taken to get around so - Essay Example Surgical treatment involves surgical excision of a tumor or an entire organ but the propensity of cancer cells to microscopically metastases makes it effective only in localized small cancers such as breast and prostate tumors. Radiation therapy can come in the form of radiotherapy, X-ray therapy and irradiation and uses ionizing radiation to kill cancer cells. Chemotherapy involves the treatment of cancer with cytotoxic drugs that can have many effects specifically geared towards the elimination of cancer cells. One of the effects of the drugs is to interfere with cell division by hindering the duplication of DNA and the separation of chromosomes. The anticancer drugs travel through the bloodstream making it useful for cancers that have spread. Monoclonal antibody therapy involves the administration of antibodies that bind to a protein on the surface of the cancer cells. Cancer treatment depends on factors such as location, degree of severity, grade of tumor and the general state of the patient. In essence, the goal of cancer treatment is to remove or destroy the malignant cells without excessive damage to the body. This is easier said than done. Indeed, the treatments mentioned are far from being the panacea for cancer as they are severely limited not only by financial challenges but also of scientific obstacles that makes it very hard for scientists to make a breakthrough in the field of cancer research. The aim of this paper is to determine the challenges facing the development of a cure of cancer. While a discussion on financial constraints would be provided, I will be focusing more on the theoretical and scientific aspects that inhibit the development of cancer cure. Possible solutions for overcoming developing cancer cure that are based on studies will then be discussed and explored to determine the principles of how it would work. 2.0 The Current State of Cancer Research 2.1 Development Processes in Clinical Studies Developing a new drug is an expensive, time-consuming process that usually takes ten years to push through. Development and determination of effectiveness of possible cancer treatment usually comes in the form clinical trials. Clinicaltrials areresearch studies wherein the treatment is applied to human patients to determine if it is effective. Regulating bodies such as the Food and Drug Administration (FDA) oversee medical and ethical panels that review the research methods and ethics of the clinical trial to be undertaken and monitor the trial phases. The standard phases are the following (Coleman, 1998): Synthesis and Purification (1st and 2nd year) - researchers identify a substance that may be useful as a drug. Animal Testing (1st and 2nd year) - the substance is tested on animals to obtain preliminary information on whether the drug is safe and how it is metabolized in the body. Phase 1 Clinical trials (3rd year) - patients who have advanced cancer and are not helped by any other known treatments are recruited for the trial. They would be subjected to an analysis for the best dosage and delivery method of a new drug treatment. Phase 2 Clinical trials (4th and 5th year) - the drug is tested with groups of patients each having a different type of cancer. This is done to determine what types of cancer can the

Theories Explaining The Cause Of Dyslexia Psychology Essay

Theories Explaining The Cause Of Dyslexia Psychology Essay According to this hypothesis dyslexia is caused due to the impairment of the phonological module which disrupts the ability to sequence the written word into its phonetic constituents[ D. Shankweiler et al,1995]. Reading is a complex process that involves two steps: decoding and comprehension[P.B. Gough,1986]. The process of comprehension requires higher order cognitive abilities like intelligence, vocabulary[D.L. Share,1995] which are left unaffected in dyslexia[Shaywitz SE,2001]. Decoding involves the conversion of graphemes to phonemes. As a result the written word is not decoded properly which makes the individual difficult to comprehend it. Support for this hypothesis comes from an fmri study conducted by Georgiewa[P. Georgiewa,2002] in which both the dyslexic and control subjects were asked to read silently the given linguistic stimuli. There was a significant activation of Inferior frontal gyrus(IFG) in the control subjects[P. Georgiewa,2002]. In the dyslexic subjects there wa s activation in 3 areas in addition to significant activation in the Brocas area. The hyper activation of Brocas area in dyslexics when compared to the controls could possibly be due to increased effort in phonological decoding. Recent anatomical evidence shows that there is a significant underactivation in Wernickes area, angular gyrus and striate cortex and overactivation in the Inferior frontal Gyrus in dyslexics when performing a phonological task[Shaywitz SE,1998]. Critics of this hypothesis argue that it doesnt account for symptoms not related to phonological decoding. Another criticism of this theory is that these phonological skills can be recovered on extensive training. This hypothesis states that the symptoms in dyslexia are causes due to the impairment of the magnocellular pathway of the Lateral Geniculate nucleus(LGN)[ Livingstone M,1991]. In their post mortem study of 5 dyslexic brains, Galaburda and their colleagues found that the M cells of the LGN were 20% smaller than that in normal people. The LGN is a six layered structure with the layers 1 and 2 known as magnocellular layer and the layers 3,4,5,6 known as the paarvocellular layer[Carlson,2007]. The Magnocellular layer is known as the faster processing pathway as they respond faster and responsible for contrast sensitivity at low spatial frequencies and low luminance levels[XuX, IchidaJM 2001, WIESELT,. N. D. H. HUBEL1. 1966].As this functional segregation of the LGN is maintained upto the cortical association areas,(posterior parietal cortex)this M-layer defect could cause impairments in reading[M. Kinsbournen 1962, Morris, R.K 1991, Olson 1991]. The theory is supported by the fact that the flicker fusion rate in dyslexics is low at conditions operated by the magnocellular layer[W.J. Lovegrove,1980].Since the major target of M cells is the Cerebellum there are possibilities where this defect in specific line of M-layer could account for the motor symptom defects in dyslexics[John Stein and Vincent Walsh,1997].The Magnocellular hypothesis has some criticisms. There is evidence against the theory that dyslexics perform worse not only in low spatial frequencies and luminance but also on high frequencies and luminance levels[Skottun, B. C, 2000]. THE DOUBLE DEFICIT HYPOTHESIS(DDH) According to this hypothesis the reading impairment caused in dyslexia is due to two deficits which are phonological and rapid naming and both are different[Wolf, M,1999]. Rapid naming deficit is a deficit in which the subjects have problem in naming different classes of stimuli when presented visually. A typical test which assesses rapid naming is Rapid Automatized naming(RAN)[ Denckla MB,1974]. According to Wolf[Wolf, M,1999], Dyslexics perform poorly on RAN. Support for this theory also comes from other researchers like Tallal, Temple[Temple 2000] who argue that dyslexic children process sounds very slowly than normal people. But Critics say that the task of rapid naming is also phonological since naming is done by spelling and producing sounds and so it involves the Brains phonological system. THE AUTOMATISATION DEFICIT HYPOTHESIS(ADH) Automatization is a process by which the process of acquisition of skill becomes finer and refined so that the skill can be performed easily. This hypothesis states that the dyslexics perform badly in any task that requires skill automatization[Nicolson,1990]. For example dyslexic children perform poorly in balancing task and the performance is poor only when they are not allowed to compensate for it consciously[Nicolson R.I and Angela J. Fawcett(1995)]. A normal child would automatize the process of hearing phonemes in a word after some period, which is difficult for dyslexic children. THE CEREBELLAR DEFICIT HYPOTHESIS(CDH) The poor performance of dyslexics on tasks that require motor skill automatization(balance task) raises a possibility that Cerebellum might the involved in Dyslexia since cerebellum is primarily involved in motor learning[J.F. Stein and M. Glickstein, 1992] and error based learning. This theory states that Dyslexia is characterised by cerebellar impairment[Nicolson, 2001]. Almost 80% of the cases of Dyslexia is characterised by Cerebellar impairment. If the cerebellum is impaired in Dyslexia then the dyslexic patients should show classic cerebellar syndromes like dystonia and ataxia[R.S. Dow and G. Moruzzi, 1958]. It was found that the performance of the dyslexics were worse than the control subjects on all the cerebellar tests[A.J. Fawcett  et al., 1996]. Direct evidence for the involvement of cerebellum in dyslexia is based on the experimental paradigm of a PET study conducted by Jenkins[I.H. Jenkins  et al, 1994]. In their study the subjects were made to learn a sequence of ke y presses by trial and error and using auditory feedback. It was found that the Cerebellum was active when the subjects learned new sequence and when the subjects were performing a prelearned sequence. The dyslexics showed less cerebellar activation (ipsilateral) both during learning of new sequence and performance of a prelearned sequence[Nicolson, 2001].One important question to answer is how cerebellar impairment could cause specific cognitive deficits in Dyslexia. The answer would be Cerebellar impairment causes problem in the childs articulatory speed which leads to reduced working memory which in turn causes language acquisition problems[S.A. Gathercole  et al, 1992]. A recent study on the morphology of Cerebellum correlates cerebellar symmetry with the degree of phonological deficit in dyslexics[Rae C,2002] indicating that there is a connection between cerebellum and phonological deficit. A lot of neuroimaging studies say that the Cerebellum is involved in language processi ng tasks[J.E. Desmond and J.A. Fiez 1998, S.G. Kim, K. Ugurbil and P.L. Strick 1994].Also abnormalities in the fronto cerebellar network is related to double deficit in dyslexics[Mark A. Eckert and Christiana M. Leonard 2003].Given all these evidences it becomes clear that cerebellum is involved in Dyslexia. But the Cerebellar deficit hypothesis also has some unanswered questions. The Cerebellum is a large structure receiving inputs from a lot of regions of the brain and so the primary impairment might be located somewhere else in the brain causing a disruption of Cerebellar processing[T. Zeffiro and G. Eden,2001].Recent research also suggests that the actual impairment might be located in the perisylvian neocortical regions[Eden, G.F. and Zeffiro, T.A. 1998, Klingberg, T. et al. 2000], which sends and receives projections from the Cerebellum. CONCLUSION Dyslexia is characterised by a wide range of symptoms and so it highly possible that the underlying defects are in multiple brain systems. Given the role of Cerebellum in Language and motor tasks, it is quite clear that cerebellum is involved in dyslexia. That said one cannot deny the PDH and MDH. Many problems in dyslexia are phonological which is in accord with the PDH. The MDH accounts for rapid processing deficits. Also Anatomical evidences described above shows that there is sufficient underactivation in the angular gyrus, Wernickes area and the magnocellular layer and the striate and extra striate cortices in dyslexics which account for the phonological and rapid processing deficits. One way of unifying these three theories is by using the fact that the Cerebellum is connected with many parts of the brain [J.D. Schmahmann and D.N. Pandya 1997, H.C. Leiner, A.L. Leiner and R. Dow 1993]. Thus I conclude by stating that Dyslexia is an impairment of multiple Brain systems.

Suicide Bombers Essay -- Suicide Attacks Islam Koran Terrorism Essays

Suicide Bombers   Ã‚  Ã‚  Ã‚  Ã‚  What makes a suicide bomber? Is it religions upbringing with promises of paradise in reward for acts of martyrdom? Is it the parental support he or she receives for his convictions? Is it society with no means of fighting back against oppression and humiliation? (http://www.israelinsider.com/channels/security/articles/sec0049.htm). In this paper I will discuss the characteristics of a suicide bomber, their mission, as well as discuss suicide attacks. Suicide Bombers   Ã‚  Ã‚  Ã‚  Ã‚  Suicide bombers are said to believe that God sends them on their missions, and by the time they are ready to be stopped with explosives, they had reached a hypnotic state. (http://www.israelinsider.com/channels/security/articles/sec0049.htm) As one can see, religion is a powerful factor. Though the Koran teaches against taking one's own life, the suicide bombers are seen as martyrs and are said to be living in the heavens. (http://www.cnn.com/2001/world/hanna.focus) However, it is stated that suicide is forbidden in Islam. However, fighting oppression is commendable, harming innocent bystanders, even in times of war, was forbidden by the prophet Muhammad. (www.israelinsider.com/channels/security/articles/sec0049.htm) Suicide bombers are very complex. They are never justified in their actions. According to Yediot Aharonot, this is the profile of a typical suicide bomber: 1.  Ã‚  Ã‚  Ã‚  Ã‚  97% of the suicide bombers have an academic education and an additional 28% have at least a high school ...

Eng 102 Poetry Essay

Denise K. Steen February 28, 2012 English 102 Option #2 Reflections Within is a non-traditional stanzaic poem made up of five stanzas containing thirty-four lines that do not form a specific metrical pattern. Rather it is supported by its thematic structure. Each of the five stanzas vary in the amount of lines that each contain. The first stanza is a sestet containing six lines. The same can be observed of the second stanza. The third stanza contains eight lines or an octave. Stanzas four and five are oddly in that their number of lines which are five and nine.Beginning with the first line in the first stanza, â€Å"The Earth's cool breeze spoke to me†, the meter examined within this line is trimeter, containing seven syllables, iambic and anapestic. The second line in the stanza, â€Å"He said, â€Å"Come to be free,† also trimeter, continues with the iambic syllable and introduces a trochee within its six syllables. The formal characteristics of the first two lines i n conjunction with its text suggests a seemingly serene beginning with a hint of possibility that something is about to change. For example, the meter is the same and the structure of the syllables in each line are similar with slight differences.The third line, â€Å"fly with me, in my winds over the seas. † contains five feet of meter or pentameter, where the pyrrhic syllable is introduced to accompany the previously introduced trochee and iambic syllables in this nine syllable line. The continuance of the second sentence into line three and then closes after â€Å"seas†, paired with the change in meter, suggests the end of consistency and a rise in to what is to come. â€Å"Be the element that I need. â€Å", the fourth , eight syllable line, is written in trimeter with trochee and anapestic syllables.This line returns us to the familiar feeling of the first two lines repeating the trimeter with trochee and anapestic syllables that are present there. The fifth lin e, â€Å"Without you, turbulent winds I stir†, nine iambic, spondee and anapestic syllables are written in tetrameter. The last line of the first stanza, â€Å"calling my anger from above striking the Earth. † is written in hexameter, containing twelve syllables of trochee, iambic and pyrrhic meters. The fifth and sixth line combined contain all of the syllables used in the first four lines of the stanza; iambic, trochee, spondee, anapestic and pyrrhic.This combination suggests the importance of all the elements of the first four lines and likewise are repeated here. Unlike the chaotic scheme of meter throughout the first stanza, the rhyme scheme is more consistent. Masculine rhyme is present here with an end rhyme of aabbcc; me, free, seas, need, stir, Earth. This more consistent pattern continues into the second stanza. In the next six lines of the second sestet the pattern becomes clearly parallel to its text. The seventh line, â€Å"As I refused, the sky started t o pound†, is measured in pentameter with iambic and pyrrhic syllables.The eighth line, â€Å"and I wondered if his love would ever be found. â€Å", repeats the pentameter and the iambic syllable but drops the pyrrhic and is replaced by the anapestic syllable. The difference in the softness of the pyrrhic two unstressed syllables and the anapest, two unstressed syllables followed by a sharper stressed syllable is symbolic of the text, exhibiting compassion during chaos. The ninth line, â€Å"I believe when the first laser like lightning cracked the sky†, fourteen syllables in hexameter with iambic, anapest and an added spondee syllable suggests a rise in the event. The tenth line, â€Å"the Earth's atmosphere surely died. exhibits a decline in its eight syllables from its previous fourteen. There is also a drop in meter from hexameter, six feet, to tetrameter of four feet. Lastly, a drop in the type of syllables in these two lines leaves us with the iambic and sponde e. These obvious declines in the formal characteristics of the text are synonymous to a decline in life or simply death. Again in the eleventh and twelth lines of the second stanza, â€Å"Dirt gray clouds filtered the air above, And just as I began to cry,† we see a repeated pattern of the tetrameter and again the iambic, anapestic and spondee syllables while dropping the anapest in the twelth line.This symbolizes the familiar that is about to proceed in the text. The rhyme scheme in the second stanza ddeefg brings us to an end in the texts' relation to the Earth's cool breeze just as the rhyme pattern discontinues from its previous flow, aabbcc. The third stanza which marks the middle of the poem begins, â€Å"The Ocean said, Come flow freely with me† with ten syllables written in pentameter accompanied by iambic, spondee and trochee syllables. A steady rhythm in meter is noted in the next four lines which declines to trimeter for all four lines. Line fourteen,  "and the creatures in my seas. contains pyrrhic, trochee and anapestic syllables. The fifteenth line in trimeter, â€Å"Here your tears will disappear,† contains for the first time in the poem, a dactyllic syllable accompanied by the iambic syllable. Line sixteen, â€Å"and your worries will cease. † contains again the iambic syllable now accompanied by the pyrrhic syllable. The last line in the series of trimeter lines is line seventeen which states, â€Å"Be the element that I need. â€Å". concludes the metered pattern. In lines fourteen through seventeen the meter is measured the same, however there is a new element added to the syllables previously used in the beginning stanzas.The repeated trimeter is suggestive of familiar situation but the new syllable is symbolic of the relation to the new element in the text, the Ocean. A change, line eighteen, â€Å"Without you, dangerous waters will come to the shores,† spikes with its thirteen syllables written in an inclined meter of pentameter and includes a mesh of anapest, dactyl, pyrrhic and iambic syllables indicating a heightening of awareness or danger. Line nineteen continues, â€Å"calling the pain from my ocean floors†, declines to tetrameter while still containing a mess of syllables, the dactyl, trochee, spondee and iambic, suggesting a heed in warning.The twentieth line concludes, â€Å"and the Earth's land will be no more. â€Å", declines to eight syllables written in tetrameter now only including the pyrrhic, spondee and iambic syllables is suggestive of a last reasonable plea before chaos begins again. The rhyme scheme in the third stanza is not one of an established category, hh (end rhyme: me, seas) ii (internal rhyme: tears, disappear) hh (end rhyme) jjj (end rhyme: shores, floors, more). There is almost an asymmetrical balance in the third stanza between the consistent formal characteristics such as the repeated meter and rhyme scheme to the variance in usage o f syllables.Both are about equal in presence suggesting that peace exists within the chaos of the text. In the fourth stanza we will observe how the text begins to transcend through its formal characteristics and signals a coming to a close or better phrased, resolution. The twenty first line continues, â€Å"As I rejected the offer he had for me†, a familiar variation of line seven, is written in hexameter with iambic, pyrrhic and trochee syllables. The next line, â€Å"White waves began to crash rythmically† lowers to tetrameter and contains nine syllables, spondee, iambic and dactyl.Here the recession in meter is suggestive in comparison to the text and signals to the reader a familiar situation seen earlier in the text. Line twenty three continues on, â€Å"and just as I began to swim†, eight syllables written in tetrameter, again, accompanied only by pyrrhic and iambic syllables signifies a hault in the pace of the text, another change, a possible resolutio n. Line twenty four reveals a slight change, â€Å"A beam of light struck through and within†, although the meter is the same as the last, the pyrrhic syllable is dropped and the anapest is added while continuing with the iambic syllable.The last line in the stanza continues, â€Å"the clouds and shown down on the Ocean's body. â€Å", one step up from tetrameter to the supporting pentameter and a few added syllables as seen before, the pyrrhic, iambic, trochee and anapestic. Stable with a slight change in formal characteristics indicates a window of hope, an open door or a light at the end of the tunnel, when compared to its subject matter. It is here where transcendence truly begins to make an appearance. The rhyme scheme in the fourth stanza is much like the pattern in the first stanza with one exception.The pattern seen here in the fourth is as follows: kkllm (me-rhythmically, swim-within, body). There is no pairing rhyme for m. Suggesting that the subject has lost some thing between the first and the fourth stanza. The final and fifth elongated stanza of nine lines begins, â€Å"It was the Earth's mother star and she said,†, in ten syllables of pentameter with trochee and iambic syllables. The twenty seventh line, â€Å"Yield your fear and dry up that tear†, has eight syllables presented in tetrameter, one less than the previous line, and one more type of syllable accompanies trochee and iambic, the spondee.The meters difference and the difference of the syllables can be interpreted as an intoduction to something new, Earth's mother star. Line twenty eight continues the statement, â€Å"that runs down your red cheek. â€Å", again a lesser amount of meter is found here as it is written in trimeter and accompanied by two types of syllables, the trochee and spondee. A slowing in the meter of these first three lines in the last stanza prepares the reader for its ending, the final resolution.In line twenty nine, â€Å"This is all just a freak of Nature's selfish ways†, the meter again rises to hexameter and introduces again a hodge podge of syllables, the pyrrhic, trochee, iambic and spondee which is suggestive of the mess â€Å"Nature† is in. Line thirty serves as a clearing of the way, â€Å"So understand these and the ones in you† written in pentameter, a decline in meter, indicating a coming to a close. Syllables trochee, spondee and iambic remain indicating stability to come. Lines thirty one through thirty four share a common meter, trimeter. However, their syllables vary slightly in each.For instance, line thirty one, â€Å"and the sky once again will be blue† written with only anapestic measures. Line thirty two, â€Å"Understand the Ocean's pain†, simply the iambic and anapestic syllables. In line thirty three, â€Å"and he too will remain tame† has an added syllable and consists of the anapest, pyrrhic and spondee supportive of a conclusion, a means to an end. A nd finally line thirty four of the five stanzas, â€Å"For these are reflections within. † in finish is settled with the repetative trimeter in eight even syllables of iambic and anapestic syllables suggesting peace, it is now over.The rhyme scheme in the fifth stanza is again unfamiliar. It is constructed as such: n-oo(internal rhyme fear, tear) pp(internal rhyme cheek, freak) q-rr(end rhyme you,blue) ss(end rhyme pain,tame) t. This unusual rhyme scheme is reflective of the texts chaotic events. The overall physical structure of the text supports a theme based on transcendence through nature. No two stanzas are alike. There is constant change in the formal characteristics as well as the text itself. Although it would seem that the chaos of these characteristics would make no sense, it makes perfect sense.There is chaos in the text so why shouldn't there be in the poem's structure? We will now explore the literary devices used throughout the poem and relate them with the domi nant patterns of imagery of Reflections Within. Synesthesia is the first device noted in the first line of the poem. Mixing the sense of feel, â€Å"The Earth's cool breeze, spoke to me†, and the audible sense is combined with the use of imagery. Personification is present here by giving air the human ability to speak. The â€Å"cool breeze† suggests what type of atmosphere the subject is experiencing. He said, Come to be free, fly with me in my winds over the seas. â€Å", suggesting the capacity to submit to feeling and be led by it to transcendence. â€Å"Be the element that I need. † Element, the word is used here as a connotation synonymous to â€Å"love†. â€Å"Without you turbulent winds I stir,† uses kinetic imagery to show motion and suggests change from love to violence. Continuing on to the closure of the first stanza, â€Å"calling my anger from above striking the Earth. â€Å", expressionism is clear here in that this line attempts to portray inner experience characterized by extreme mood or feeling with violent exaggeration.In this first stanza the atmosphere has set the mood that something is uneasy, that there is a conflict or a problem even if unclear at this stage. The second stanza continues the conflict in its first and second lines, â€Å"As I refused, the sky started to pound, and I wondered if his love would ever be found. † suggests a sense of helplessness by the subjects' inability to console the pain of the Earth's cool breeze. â€Å"I believe when the first laser like lightning cracked the sky, the Earth's atmosphere surely died. † several literary devices are used here such as the onomatopoeia â€Å"cracked† resembling the sound that lightning makes.Another connotation is observed in â€Å"atmosphere† used in place of â€Å"heart†. Personification is repeated here in giving the Earth the sense of life through death and dying. The smoothness of the rhyme scheme up until this point in the text is consistent until the next two lines interfere with the structure. â€Å"Dirt gray clouds flitered the air above,† again a change is indicated here suggesting that a new setting is approaching. â€Å"And just as I began to cry,† suggests a sense of helplessness again in that the situation is familiar and unchanging or worsening.Turning to the third stanza the subject finds themselves again in a familiar situation with the Ocean, cornered . â€Å"The Ocean said, Come flow freely with me, and the creatures in my seas† synethesia is evident in the Ocean's ability to speak and make an offering. â€Å"Here your tears will disappear, and your worries will cease. † a promise of security. â€Å"Be the element that I need. † the same connotation made of the word element previously, stands firm here as well. In return, the Ocean asks for love. â€Å"Without you dangerous waters will come to the shores, calling the pain from my ocean floors and the Earth's land will be no more. A condition to the offering, conditional love, which is not truly love at all if it is consequential. This suggests that things aren't quite what they seem in this serene image of ocean waters. This central stanza recalls a similar situation from the first two verses supporting the relationship between the self and nature. It also marks the central high point or climax which eventually must descend. â€Å"As I rejected the offer he had for me,† a variation of the familiar line seven, suggests the beginning of another familiar problem, rejection, in the first line of the fourth stanza. White waves began to crash rhythmically†, kinetic imagery is used here in the word rhythmically which gives motion to the entire phrase suggesting change. There is a change in the mood of the Ocean from calm and serene to violent waves. â€Å"Crash† is used as an onomatopoeia, as the sound waves would make when â€Å"crashingâ €  upon one another. â€Å"And just as I began to swim†, we have now transcended in nature from flying with the winds to swimming in the seas, hence, transcending through nature to locate the genuine. â€Å"A beam of light struck through and within† suggestive of a glimmer of hope, the â€Å"light†. Through and within†, symbolic of the heart or soul, the genuine. â€Å"The clouds and shown down on the Ocean's body†, resolution! The light revealing the Ocean's body puts a stop to its misbehavior, like a child when caught bullying a sibling. This beginning of a resolution signals the root of the subjects' dilemna. â€Å"It was the Earth's mother star and she said,†, again an inatimate object is given human characteristics in speaking, symbolizing personification. Security can be suggestive of the mother star as it is located â€Å"above† all else and is given a godly sense. One that is reveared with power, love, sterness and compassio n.The same as a loving parent or â€Å"mother†. â€Å"Yield your fear and dry up that tear, that runs down your red cheek†, just as a mother would wipe the tears from a crying child's eyes. â€Å"This is all just a freak of nature's selfish ways† here the transcendence between the self and nature come together. â€Å"So understand these and the one's in you, and the sky once again will be blue† is suggestive of oneness with nature, or one in the same, the self. â€Å"Understand the Ocean's pain, and he too will remain tame†, personification is given again to the Ocean giving it the ability to understand or feel pain.This line also exhibits oneness with nature. â€Å"For these are reflections within. † could suggest dramatic monologue being that it is unknown if the author intended to reveal that the reactions of the earthly elements were deeply rooted in the self. This romantic didactic poem shows us that one may have control over what happe ns around them depending on thier outlook on life and how one handles their emotions. Moving on to examining the formal characteristics of William Wordsworth's poem, I wandered lonely as a cloud which shares a common theme with the previous poem Reflections Within, transcendence through nature.I wandered lonley as a cloud is a romantic stanzaic poem consisting of four stanzas each made up of a sestet or six lines for a total of twenty four lines. The first five lines, I wandered lonely as a cloud That floats on high o'er vales and hills When all at once I saw a crowd, A host of golden daffodils, Beside the lake, beneath the trees, are all written in iambic tetrameter. A change is indicated at the end of the stanza when the metered pattern changes as does the rhyme scheme simultaneously. Line six, â€Å"Fluttering and dancing in the breeze. † is nine syllables written in tetrameter accompanied now by an anapest and iambic syllables.The change in rhyme scheme from abab ending t he stanza in cc represents the stable basis that will be repeated throughout the transcendence of the text. The same is noted for the end rhyme scheme of the text per each stanza. The second stanza, Continuous as the stars that shine And twinkle on the milky way, They stretched in never-ending line Along the margin of a bay: alternates between nine and eight syllables, consistent in the rhyme scheme here as dede. All four lines are identical to the formal structure of the previous tetrameter measured lines in the first stanza.However, there is a notable change in the existence of syllables besides the iamb such as the anapest, pyrrhic, trochee, dactyl, and spondee which includes all possible combinations of syllables, suggesting that the text reaches beyond the tangable, including all things, the universe. Lines eleven and twelve of the second stanza stand again as a steady base, Ten thousand saw I at a glance, Tossing their heads in sprightly dance. to support the previous four lin es with its double end rhyme scheme gg, accompanied by eight syllables per line, also written in tetrameter to reinforce the supporting repeated pattern of the subject in text.The third stanza, The waves beside them danced; but they Out-did the sparkling waves in glee; A poet could not but be gay, In such jocund company; I gazed – and gazed- but little thought What wealth the show to me had brought: again continues the same previous pattern of end rhyme, hihijj. Still consistent with the meter measured as tetrameter. Again a conglomorant of syllables are used such as the iamb, pyrrhic, spondee and a trochee which suggests the continuing of the worldly idea and that everything is in place just as it was intended, the way nature intended it. The last stanza in sestet,For oft, when on my couch I lie In vacant or in pensive mood, They flash upon that inward eye Which is the bliss of solitude; And then my heart with pleasure fills, And dances with the daffodils. reverts back to th e structure seen in the first stanza written in iambic tetrameter which is similar to the texts' suggestive flashback. Keeping the flow of the rhyme scheme to its completedness, klklmm is suggestive of a repeated pattern, similar to the subject of the text, a place to be revisited. The overall structure of this text is very organized with regular meter and rhyme.Similar in the way that nature also has a specific order. Transcendence does not make itself obvious here in the physical structure, rather it makes somewhat of a circle reverting back to its original state, similar in the way that nature rejuvinates itself. Wordsworths' words in this text are used as a capacity to submit to feeling and be led by it to transcendence through the use of literary devices and dominant patterns of imagery which we will now examine. The first line, â€Å"I wandered lonely as a cloud† establishes personification, as if a cloud would purposefully think to wander such as a person might do. Tha t floats on high o'er vales and hills†, the beginning of a presented journey. â€Å"When all at once I saw a crowd,† suggests change or something new and exciting. â€Å"A host, of golden daffodils,† a host, suggests a party of people. Perhaps a â€Å"crowd† of people at a gathering. â€Å"Beside the lake, beneath the trees†, suggestive of an out-door event, a reunion or union of such. â€Å"Fluttering and dancing in the breeze† allows the image to become kinetic in setting motion to the â€Å"crowd† of daffodils that are fluttering and dancing amongst themselves, as socialites do at a wedding. Continuous as the stars that shine, And twinkle on the milky way†, suggests an imagery of beauty that goes far beyond what the eye can see. â€Å"They stretched in never-ending line, along the margin of the bay;† suggests a pause as if they were waiting for something. â€Å"Ten thousand saw I at a glance,† suggests a feeling of being overwhelmed by the sight and therefor is exaggerated. â€Å"Tossing their heads in sprightly dance. † uses kinetic imagery to suggest again change. This imagery could be symbolic of bachelorettes waiting in line to catch the bouquet, to make the transformation from bachelorette to bride.The sprightly motion is a feminine suggestion that supports this image. â€Å"The waves beside them danced; but they Out-did the sparkling waves in glee† suggests that even the beauty of the water was no match for the joy of the daffodils. â€Å"A poet could not but be gay, In such a jocund company;† again the insinuation of a group suggests people, in this case of good company. â€Å"I gazed – and gazed but little thought What wealth the show to me had brought† suggests that the subject took the moment for granted and like the fourth stanza, the moment comes to an end. For oft when on my couch I lie In vacant or in pensive mood,† suggests that we are back in the atmosphere of the first stanza wandering lonely as a cloud. â€Å"They flash upon that inward eye†, a connotation of â€Å"inward eye† locates the genuine here, flashing back to the imagination or the mind. â€Å"Which is the bliss of solitude†, suggests that the subject is content with being alone, not restrained by the ties of marriage, enititled to private thought and to think whatever one should want. And then my heart with pleasure fills, And dances with the daffodils† suggests that the subject returns to the nature of being man and appreciates the beauty in nature, be it flower or woman, he has the option to pick from this metaphor. The conclusion of the text recycles the subject back to the familiarity of the beginning text. Transcendence through nature in this text reflects the relationship between the self and the beauty of nature. Reflections Within and I wandered lonely as a cloud are two poems that share the common theme, transcend ence through nature.The major differences between the two text is that the subject in Reflections Within does not achieve being at one with nature until the end of the poem and is supported by its chaotic line structure and variances in syllables and meter. Whereas the second texts' subject is completely at one with nature throughout the entirety of its text and is mirrored in the confindence of the repeated line structure, rhyme scheme and meter. The main focus of both subjects is escape however they differ in motivation. While one subject is trying to escape the negative nature of self, the other escapes to nature in positive imagery.Locating the authentic in both of these texts also differs. The genuine in Wordworth's poem is located in the head or the mind of the subject. The authentic or genuine is located in the heart of the subject of Reflections Within. Both texts are similar in the elements of nature that are used in order to transcend the character through nature such as t he breeze, stars and water or waves. Both texts treat nature with human characteristics such as speaking, dancing and many other motions which are necessary to transcend. Overall both texts treat nature as a source for authenticity and spiritual refreshment.

Internet Privacy Essay

Electronic commerce (e-commerce) is a great opportunity for any fledging entrepreneur to expose his goods to buyers all over the world through the internet. Small and medium scale businesses, with the right mixture of products and e-commerce capabilities can thrive in a global market. Geography is now longer a hindrance. One doesn’t even need a great amount of capital outlay to get started. For $ 25 a month, one can get an e-commerce start up kit (â€Å"Exploring E-Commerce†). Every imaginable commodity is now sold on-line. It would be wise for any business minded person to ride the information age. Of course, one area of concern when it comes to electronic transactions is security. There have been many instances where credit card information submitted to certain business related websites were stolen and used for other purposes. Customers would need some measure of guarantee that they are not getting scammed. At the same time, businessmen, especially the newer ones, would like to minimize costs of implementing a highly secure environment. Like everything else, a balance must be reached between security for the customer and cost for the business owner. The advantage of a non-secure e-commerce environment is that the business can start right away, even at the comfort of your own home if you prefer. Starting capital would be affordable since one only needs to register a website name and post the products he is offering. The site functions as a showroom for global customers. The disadvantage is that the number of hits on the site doesn’t necessarily translate to customers. 54% of prospective buyers cancel their transactions because of concerns which include insecurity (â€Å"Exploring E-Commerce†). Another disadvantage is that safe payment options are limited. Because non-secure e-commerce sites are vulnerable to hacker attacks, customers would prefer not to use any kind of electronic payment. This would limit the customer’s options to bank deposits and cash-on-delivery schemes. If credit card payment is offered in an insecure web environment, the risk of theft is increased. Overly secured e-commerce sites provide the customer with a blanket of safety and convenience for both the customer and the site owner. With up to date security measures, the owner opens his business to the more than 1. 2 billion credit card owners, world wide (â€Å"Exploring E-Commerce†). Applying encryption methods such as the widely accepted secure socket layer (SSL) certificates on the business website shields important customer information, like credit card numbers, from hackers and other web predators. One disadvantage of a highly secure e-commerce setup is the cost in putting up the safeguards. Verisign, the company that offers SSL certificates, charges over $1,000 for an extended SSL good for 1 year (â€Å"Verisign†, 2007). Other security costs include purchasing and updating of anti-virus software and firewall infrastructure. A minor inconvenience for the customer would be repeated input of customer information including passwords to help secure a transaction. These are not one time only costs. SSL and anti-virus software need regular updates to adapt to relentless hackers and virus code programmers. Even with all of these, there is still no 100% guarantee that the e-business is safe since security is meant to â€Å"manage not eliminate risks† (Tung, 2007). If the entrepreneur is new to the e-commerce business and confined with a limited budget, it is advisable that he start with registering the website first and live with the payment limitations. If the product is good, and the owner makes up for the limitations with above average service like on time delivery and packaging, then he may gradually add components that would make his e-business more secure. If money is no object to the businessman, then adding market accepted security features will certainly not hurt and will even attract repeat business. References: E-commerce 101. Retrieved December 10, 2007, from Sell it on the web Web site: http://sellitontheweb. com/ezine/webstore101. shtml Exploring E-Commerce. Entrepreneur. com , Retrieved December 10, 2007, from http://www. entrepreneur. com/growyourbusiness/howtoguides/article81238. html Tung, Liam (2007, November 2007). ‘Friendly rootkits’ proposed for safe e-commerce. Retrieved December 10, 2007, from ZDNet. co. uk Web site: http://news. zdnet. co. uk/internet/0,1000000097,39291134,00. htm? r=2 Verisign (2007). Retrieved December 10, 2007, Web site: https://ssl-certificate- center. verisign. com/process/retail/product_selector? uid=f149c3d301a629c3897d6187982dbfe7